Activation of the Renin - Angiotensin System Specifically in the Subfornical Organ 2 is Sufficient to Induce Fluid Intake 3 4

1 1 Activation of the Renin-Angiotensin System Specifically in the Subfornical Organ 2 is Sufficient to Induce Fluid Intake 3 4 Jeffrey P. Coble, Martin D. Cassell, Deborah R. Davis, Justin L. Grobe, and Curt D. 5 Sigmund 6 7 8 Department of Pharmacology and Department of Anatomy and Cell Biology Roy J. 9 and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA 10 11 12 Short title: SFO ANG induces fluid intake through PKC 13 14 15 16 Corresponding Author: 17 Curt D. Sigmund, Ph.D. 18 Department of Pharmacology 19 Roy J. and Lucille A. Carver College of Medicine 20 University of Iowa 21 375 Newton Rd., 3181 MERF 22 Iowa City, Iowa, 52242 23 Phone: 319-335-7604 24 Fax: 319-353-5350 25 E-mail: [email protected] 26 27 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (June 25, 2014). doi:10.1152/ajpregu.00216.2014